Oh man but it's been a while since I played but I largely invested points in biotic and tech stuff. Combat points it was only points into assault rifles and the ones that would increase health, shields etc.
Think I just stuck with the vanguard profile for the most part with a couple of different setups
Charge, Nova and Shockwave - Really good for close range fighting
Singularity, pull and throw - Better for outdoors and fighting non kett enemies
I would use the Infiltrator profile such as
Overload, energy drain and AI squadmate or invisibility - Used this for when fighting the robots and any enemies with shields. Invisibility is handy if your health gets low.
As far as weapons go I pretty much just used the N7 Valkyrie assault rifle and upgraded to higher levels when I could. I used the heat sink mod with it so I didn't need to run around looking for ammo all the time.